Just like Despicable Me, this movie is about a super villain. Megamind is born on another planet, and his parents put him in a ship and send him to Earth just before their planet is consumed by a black hole. On the way to Earth, he runs into another ship with another baby. While the other baby lands in a mansion, Megamind lands in a prison for the criminally gifted. He goes to school with the other alien, who has super powers and is admired by all the other kids. Megamind is shunned, and he realizes he might as well be a villain. Nice little message about how we are all products of our environments.
Megamind's goal in life is to defeat his nemesis, Metro Man. When he finally does, he discovers that life is very boring without his enemy. He decides to try and create a new super hero to fight. In the mean time, he has a crush on Metro Man's girlfriend, a TV reporter.
The movie is very funny, and a nice twist on the typical super hero story.